Guillermo Galindo's work spans a wide spectrum of artistic expression, from symphonic composition to musical computer interaction, electro-acoustic music, opera, film music, instrument building, multimedia installation, and sound design. His music has been performed and shown at major festivals and art exhibits throughout the United States, Latin America, Europe, and Asia.

Guillermo's second symphony, Trade Routes, for orchestra, spoken word, and chorus, with text by San Francisco poet laureate Devorah Major, was recently performed as the season opener for the Oakland East Bay Symphony Orchestra's 2005?6 season.

He has also written two operas: Califas 2000, with text and performance art by MacArthur Fellow Guillermo Gomez Peña, and Decreation: Fight Cherries. The latter includes text by MacArthur Fellow Anne Carson and premiered at CCA in 2001.

His most recent work focuses on music as ritual, live audience interaction, the creation of cyber-totemic / interactive sound objects, symbolism, and site-specific sound environments.